I have a very small leak in a pvc drain pipe. I can't get a tube of caulk to it without taking half the house apart. If I just filled the entire area around that pipe with this stuff would it seal the leak?

Thank you for your question. Although OSI QUAD Foam will adhere to PVC pipe it would not be recommended for stopping a leak in a pipe. There are products designed for this purpose such as epoxies or tapes, depending upon the nature of the leak.