Will this remove a check engine light? Does this work for a 2012 Buick Enclave?

It really depends on the OBD being a feature of your car. On-board diagnostics (OBD) is a term referring to a vehicle's self-diagnostic and reporting capability so it will depend on the information the car's system sends to our model. We can not specify if it will remove a check engine light/it will work with a car by just the brand or the model. You will need to check those doubts with a mechanic.