Can the fence be removed? Is there an easy guide or stop when putting the fence in and it be inline with the center or off center from the router?

Yes, you may remove the fence as it is removable. With regard to installation of it kindly follow what's in the manual: ASSEMBLING THE FENCE 1. Insert the pins molded into the top of the vacuum port (13) into the holes on the rear of the aluminum fence (11), as shown in Fig. 5. 2. From the underside of the fence, insert two #10-32 x 5/8″ countersunk machine screws (33) up through the holes in the bottom of the fence and vacuum port. Secure in place with two #10-32 KEPS nuts (24) (Fig. 5). 3. Place the fence right-side-up on a flat surface and align the counter bored holes in the fence facings (12) with the slotted holes in the fence. The counter bored side of the facings should face OUT (Fig. 6). 4. Attach both fence facings (12) to the front of the fence, using two 1/4-20 x 1″ carriage bolts (34) and two large clamping knobs (14) for each fence facing (Fig. 6). 5. From the front of the overhead guard (15), insert two 1/4-20 x 11⁄2″ carriage bolts (31) through the holes in the guard. Slide a spacer (16) on each bolt so that the tabs on the spacers fit into the slots on the guard. 6. From the front of the fence, insert the carriage bolts through the holes in the top center of the fence. The tabs on the spacers will fit into the top channel on the fence. Secure in place with a small clamping knob (17) on each bolt (Fig. 6). NOTE: To simplify installation of the router adapter plate and router, do not install the fence onto the router table at this time. For further assistance, contact us at 1-877-BOSCH99 (1-877-267-2499) from Mon-Fri 7A-7P CST.